THERAPY OF ENDOCRINE DISEASE: Endocrine dilemma: management of Graves’ orbitopathy

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THERAPY OF ENDOCRINE DISEASE: Endocrine dilemma: management of Graves' orbitopathy.

Management of Graves' orbitopathy (GO) must be based on the correct assessment of activity and severity of the disease. Activity is usually assessed with the Clinical Activity Score, whereas severity is classified according to a European Group On Graves' Orbitopathy (EUGOGO) consensus statement as mild, moderate-to-severe, and sight-threatening. Myopathic and chronic congestive forms are uncomm...

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ENDOCRINE DILEMMA: Management of Graves Orbitopathy

Management of GO must be based on a correct assessment of activity and severity of the disease. 1 Activity is usually assessed with the Clinical Activity Score (CAS), while severity is classified, 2 according to a EUGOGO consensus statement as mild, moderate-to-severe and sight-threatening. A 3 myopathic and the chronic congestive forms are uncommon clinical presentations of GO. 4 Restoration a...

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Rituximab (RTX) use in open-label series has been associated with very encouraging responses in patients with active and moderate-to-severe Graves' orbitopathy (GO). Recently, randomized controlled trials of RTX have been performed in such patients to answer the question of clinical efficacy and the safety profile of this agent. That data, reported separately, focused on Clinical Activity Score...

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 2016

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje-15-1164